Less sleep, less inflammation? Aspirin may reduce inflammation caused by sleep deprivation

The findings, to be presented at the ongoing SLEEP 2024 Annual Meeting in Texas, US, show that preemptive administration of low-dose aspirin during sleep deprivation reduces inflammatory responses.

Bhoomi Goyal
Published on: 4 Jun 2024 9:22 AM GMT
Less sleep, less inflammation? Aspirin may reduce inflammation caused by sleep deprivation
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Low-dose acetylsalicylic acid, also known as aspirin, may reduce inflammation in people suffering from sleep deprivation, according to a new study.

The findings, to be presented at the ongoing SLEEP 2024 Annual Meeting in Texas, US, show that preemptive administration of low-dose aspirin during sleep deprivation reduces inflammatory responses.

"Specifically, aspirin reduced the expression of interleukin-6 and COX-1/COX-2 double-positive cells in lipopolysaccharide-stimulated monocytes, as well as C-reactive protein serum levels," said researchers from Harvard Medical School.

Larissa Engert from the school's Beth Israel Deaconess Medical Center said the study investigated whether the consequences of inflammation caused by sleep deprivation could be reduced pharmacologically.

Engert, who is the lead author, said, “We used a non-steroidal, anti-inflammatory drug because it has been shown to affect specific inflammatory pathways that have previously been shown to be dysregulated by experimental sleep deprivation or sleep disturbance.”

The team collected data from 46 healthy adults, both in the hospital and at home, subjected to three scenarios: sleep deprivation/aspirin, sleep deprivation/placebo, and control sleep/placebo, in a randomized placebo-controlled crossover trial.

According to Engert, the aspirin-induced reduction in inflammatory pathway activity in sleep-deprived participants was paralleled by a decrease in wakefulness after sleep onset and an increase in sleep efficiency during recovery sleep. He noted that “the findings demonstrate that it is possible to reduce activated inflammatory pathways due to sleep deprivation through the preemptive administration of low-dose aspirin.”

The study may help advance new therapeutic approaches “that complement behavioral methods of sleep improvement therapy to better prevent or control inflammation and its consequences, and importantly, do not cause aspirin-associated side effects such as bleeding and stroke.”

Bhoomi Goyal

Bhoomi Goyal

English Content Writer in Newstrack from Jaipur, Rajasthan. (Education, Business, Technology, Political, Sports, Lifestyle, Crime and Webstories)

My self Bhoomi Goyal from Jaipur, Rajasthan. I have passed my Master's in Journalism and Mass Communication this year. I worked in Rajasthan Patrika for six months as an intern. I am working here from June 1st. I passed my graduation in BCA from Rajasthan University and master's in journalism and mass communication from Vivekananda Global University, Jaipur.

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